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particularly oxidative and nitrosative stress pathways where it increases the oxidative burden, further triggers reactive nitrogen species (RNS, e.g., nitric oxide) and reactive oxygen species (ROS) effects of excitotoxicity and mitochondrial dysfunction

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The information on the influence of nicotine on intestinal microbiota is partly observational, a great deal of research work thus is needed to explore the mechanism of nicotine-induced dysbiosis of the intestinal microbiome